Description
Human adherent, PC-9 (previously known as PC-14), is a cell line derived from human lung adenocarcinoma, a non-small cell lung cancer (NSCLC) consisting of a heterogeneous mixture of round and spindle-shaped cells.
PC-9 cells are often used as a model for studying lung cancer, including the molecular mechanisms involved in its development and progression and targeted therapies. PC-9 cells are particularly notable for harboring a deletion mutation in exon 19 of the EGFR gene. The mutations make the cells responsive to EGFR tyrosine kinase inhibitors (TKIs), which are used in the treatment of some lung cancers. Thus, PC-9 cells serve as a model to study resistance to tyrosine kinase inhibitors (TKIs) in lung cancer
This cell line is transformed by lentivirus transduction. The expression cassette listed below was integrated into cell line’s genome.
This CRISPR ready (Cas9 expression) stable cell lines make the genomic editing easier than ever in human PC-9 cell line. You simply deliver the target specific gRNA into the CRISPR ready cell line and select the knock-out or knock-in cells for your desired target. You only need to generate the target-gRNA constructs. GenTarget also provide services to generate your target specific, ready-to-use gRNA lentivirus. Please contact us if you need the CRISPR gRNA lentivirus services.
Sold at: 1 vial x (2 x 106 cells)/vial , Product Manual.
Cat# SC095-Cas9
