Description
Human adherent, PC-9 (previously known as PC-14), is a cell line derived from human lung adenocarcinoma, a non-small cell lung cancer (NSCLC) consisting of a heterogeneous mixture of round and spindle-shaped cells.
PC-9 cells are often used as a model for studying lung cancer, including the molecular mechanisms involved in its development and progression and targeted therapies. PC-9 cells are particularly notable for harboring a deletion mutation in exon 19 of the EGFR gene. The mutations make the cells responsive to EGFR tyrosine kinase inhibitors (TKIs), which are used in the treatment of some lung cancers. Thus, PC-9 cells serve as a model to study resistance to tyrosine kinase inhibitors (TKIs) in lung cancer
Gentarget generated this Luciferase reporter cells, transformed by luciferase lentivirus transduction. This cell line expresses the firefly luciferase gene under the enhanced EF1a promoter. It also carries the Puromycin resistance under Rsv promoter. The cell line demonstrates high level of bioluminescence signal via firefly luciferase assay. The following express cassette was integrated into cell line’s genome.
Sold at: 1 vial x (2 x 106 cells)/vial, see details in Product Manual.
Cat# SC095-Luc
